論文 - 詳細
| RRC ID | 77037 |
|---|---|
| 著者 | Shigematsu N, Kawashiri T, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T. |
| タイトル | Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro. |
| ジャーナル | Sci Rep |
| Abstract |
Oxaliplatin is a platinum-based antineoplastic drug commonly used for treating colorectal, gastric, and pancreatic cancer. However, it frequently causes peripheral neuropathy as dose-limiting toxicity and is lacking a strategy for prevention. Alogliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, is an oral antidiabetic drug. Previous studies have shown that DPP-4 inhibitors have pleiotropic effects, including neuroprotection. In this study, we investigated the effects of alogliptin on oxaliplatin-induced peripheral neuropathy using in vitro and in vivo models. In PC12 cells, alogliptin attenuated neurite disorders induced by oxaliplatin and cisplatin. The repeated injection of oxaliplatin caused mechanical allodynia and axonal degeneration of the sciatic nerve in rats. These neuropathies were ameliorated by co-administration of alogliptin. Moreover, alogliptin did not attenuate tumor cytotoxicity of oxaliplatin in the cultured colon, gastric, or pancreatic cancer cell lines and tumor-bearing mice. These findings suggest that alogliptin may be beneficial for preventing oxaliplatin-induced peripheral neuropathy. |
| 巻・号 | 10(1) |
| ページ | 6734 |
| 公開日 | 2020-4-21 |
| DOI | 10.1038/s41598-020-62738-w |
| PII | 10.1038/s41598-020-62738-w |
| PMID | 32317735 |
| PMC | PMC7174301 |
| MeSH | Allografts Animals Antineoplastic Agents / adverse effects* Axons / drug effects Axons / pathology Cell Differentiation / drug effects Cell Line, Tumor Cisplatin / adverse effects* Colonic Neoplasms / drug therapy Colonic Neoplasms / pathology Dose-Response Relationship, Drug HCT116 Cells Humans Hyperalgesia / chemically induced Hyperalgesia / physiopathology Hyperalgesia / prevention & control* Male Mice Mice, Inbred BALB C Neurites / drug effects Neurites / pathology Neuroprotective Agents / pharmacology* Oxaliplatin / adverse effects* PC12 Cells Peripheral Nervous System Diseases / chemically induced Peripheral Nervous System Diseases / physiopathology Peripheral Nervous System Diseases / prevention & control* Piperidines / pharmacology* Rats Rats, Sprague-Dawley Sciatic Nerve / drug effects Sciatic Nerve / physiopathology Tumor Burden / drug effects Uracil / analogs & derivatives* Uracil / pharmacology |
| IF | 3.998 |
| リソース情報 | |
| ヒト・動物細胞 | HCT116(RCB2979) |