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  • Search Condition : Filter (MeSH = Piperidines / pharmacology*)
Species Resource Title
DNA material pEU-E01-NLRP3-FL-Bls (RDB19445) , pEU-E01-FLAG-ASC-PYD (RDB19446) , pEU-E01-FLAG-ASC-CARD (RDB19447) KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle-Wells syndrome.
Human and Animal Cells PC-12(RCB0009) Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.
Human and Animal Cells Ba/F3 Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
Human and Animal Cells RAW 264(RCB0535) Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
Human and Animal Cells PC-12(RCB0009) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.
Human and Animal Cells KP4(RCB1005) Translational pharmacokinetic-pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose.
Human and Animal Cells Ba/F3(RCB0805) , LC-2/ad(RCB0440) Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.
Human and Animal Cells NH-12(RCB2108) Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
Human and Animal Cells CACO-2(RCB0988) Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases.
Human and Animal Cells Ba/F3(RCB0805) , II-18(RCB2093) , A431(RCB1872) Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression.
Human and Animal Cells EL4(RCB1641) Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.
Human and Animal Cells PANC-1(RCB2095) , MIA Paca2(RCB2094) Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.
Human and Animal Cells ATDC5(RCB0565) Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.
Human and Animal Cells RAW 264(RCB0535) Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation.
C.elegans NA Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Human and Animal Cells C2C12(RCB0987) Acetylcholinesterase inhibitors attenuate angiogenesis.
Human and Animal Cells PC-12(RCB0009) Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors.
Human and Animal Cells Lafutidine inhibits Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells.
Human and Animal Cells MEB4(RCB1027) Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.
Human and Animal Cells ATDC5(RCB0565) Inhibition of insulin-induced chondrogenic differentiation of embryonic carcinoma cells by a teratogenic compound YM9429.