論文 - 詳細
| RRC ID | 77150 |
|---|---|
| 著者 | Mawardi H, Giro G, Kajiya M, Ohta K, Almazrooa S, Alshwaimi E, Woo SB, Nishimura I, Kawai T. |
| タイトル | A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw. |
| ジャーナル | J Dent Res |
| Abstract |
No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (BONJ). Therefore, the present study examined the effects of oral bacteria on the development of BONJ-like lesions in a mouse model. In the pamidronate (Pam)-treated mice, but not control non-drug-treated mice, tooth extraction followed by oral infection with Fusobacterium nucleatum caused BONJ-like lesions and delayed epithelial healing, both of which were completely suppressed by a broad-spectrum antibiotic cocktail. Furthermore, in both in vitro and in vivo experiments, the combination of Pam and Fusobacterium nucleatum caused the death of gingival fibroblasts (GFs) and down-regulated their production of keratinocyte growth factor (KGF), which induces epithelial cell growth and migration. Therefore, in periodontal tissues pre-exposed to bisphosphonate, bacterial infection at tooth extraction sites caused diminished KGF expression in GFs, leading to a delay in the epithelial wound-healing process that was mitigated by antibiotics. |
| 巻・号 | 90(11) |
| ページ | 1339-45 |
| 公開日 | 2011-11-1 |
| DOI | 10.1177/0022034511420430 |
| PII | 0022034511420430 |
| PMID | 21921248 |
| PMC | PMC3188458 |
| MeSH | Animals Anti-Bacterial Agents / therapeutic use Apoptosis Bone Density Conservation Agents / adverse effects Cell Movement Cell Survival Cells, Cultured Diphosphonates / adverse effects Disease Models, Animal Epithelial Cells / metabolism Epithelial Cells / microbiology Female Fibroblast Growth Factor 7 / biosynthesis Fibroblasts / metabolism Fibroblasts / microbiology Fusobacterium nucleatum / pathogenicity* Gingiva / cytology Gingiva / microbiology Jaw Diseases / chemically induced Jaw Diseases / microbiology* Mice Osteonecrosis / chemically induced Osteonecrosis / microbiology* Pamidronate Surgical Wound Infection / drug therapy Surgical Wound Infection / microbiology* Tooth Extraction / adverse effects |
| IF | 4.914 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | GE1(RCB1709) |