論文 - 詳細
| RRC ID | 77218 |
|---|---|
| 著者 | Liu Y, Ding L, He J, Zhang Z, Deng Y, He S, Yan X. |
| タイトル | A new antibacterial chromone from a marine sponge-associated fungus Aspergillus sp. LS57. |
| ジャーナル | Fitoterapia |
| Abstract |
Chemical investigation for the secondary metabolite of marine-derived fungus Aspergillus sp. LS57 resulted in the isolation of one new chromone named aspergilluone A (1) containing a chromone skeleton fused with an unusual hydrogenation cyclopentanoid ring, along with three known compounds 2-4. The structure of 1 was elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analyses. Its absolute configuration was established by combining NMR quantum chemical calculations and comparison between the experimental and calculated circular dichroism (CD) curves. Additionally, the antibacterial assay of compound 1 was performed. As a result, compound 1 showed in vitro anti-Mycobacterium tuberculosis with MIC value of 32 μg/mL, together with moderate antibacterial activity against Staphylococcus aureus (MIC values = 64 μg/mL), and exhibited feeble activity against gram-positive Bacillus subtilis and gram-negative pathogen Escherichia coli (both MICs = 128 μg/mL). |
| 巻・号 | 154 |
| ページ | 105004 |
| 公開日 | 2021-10-1 |
| DOI | 10.1016/j.fitote.2021.105004 |
| PII | S0367-326X(21)00179-9 |
| PMID | 34339802 |
| MeSH | Animals Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Aspergillus / chemistry* China Chromones / isolation & purification Chromones / pharmacology* Microbial Sensitivity Tests Molecular Structure Porifera / microbiology* |
| IF | 2.527 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1465, JCM 1649 |