| RRC ID |
77330
|
| 著者 |
Hsu WL, Hsieh YT, Chen WM, Chien MH, Luo WJ, Chang JH, Devlin K, Su KY.
|
| タイトル |
High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulation.
|
| ジャーナル |
Dis Model Mech
|
| Abstract |
To understand the effects of a high-fat diet (HFD) on lung cancer progression and biomarkers, we here used an inducible mutant epidermal growth factor receptor (EGFR)-driven lung cancer transgenic mouse model fed a regular diet (RD) or HFD. The HFD lung cancer (LC-HFD) group exhibited significant tumor formation and deterioration, such as higher EGFR activity and proliferation marker expression, compared with the RD lung cancer (LC-RD) group. Transcriptomic analysis of the lung tissues revealed that the significantly changed genes in the LC-HFD group were highly enriched in immune-related signaling pathways, suggesting that an HFD alters the immune microenvironment to promote tumor growth. Cytokine and adipokine arrays combined with a comprehensive analysis using meta-database software indicated upregulation of C-reactive protein (CRP) in the LC-HFD group, which presented with increased lung cancer proliferation and metastasis; this was confirmed experimentally. Our results imply that an HFD can turn the tumor growth environment into an immune-related pro-tumorigenic microenvironment and demonstrate that CRP has a role in promoting lung cancer development in this microenvironment.
|
| 巻・号 |
16(11)
|
| 公開日 |
2023-11-1
|
| DOI |
10.1242/dmm.050360
|
| PII |
334577
|
| PMID |
37929799
|
| MeSH |
Adenocarcinoma of Lung* / genetics
Animals
C-Reactive Protein
Diet, High-Fat
ErbB Receptors / genetics
Lung Neoplasms* / genetics
Mice
Mice, Transgenic
Tumor Microenvironment
|
| IF |
4.651
|
| リソース情報 |
| ヒト・動物細胞 |
PC-14(RCB0446) |
