論文 - 詳細
| RRC ID | 77577 |
|---|---|
| 著者 | Yamazaki Y, Abe Y, Fujii S, Tanaka KF. |
| タイトル | Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. |
| ジャーナル | Nat Commun |
| Abstract |
The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na+-K+-Cl- co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain. |
| 巻・号 | 12(1) |
| ページ | 5146 |
| 公開日 | 2021-8-26 |
| DOI | 10.1038/s41467-021-25488-5 |
| PII | 10.1038/s41467-021-25488-5 |
| PMID | 34446732 |
| PMC | PMC8390751 |
| MeSH | Animals Axons / metabolism* Brain / cytology Brain / physiology* Female Learning Male Mice Neuronal Plasticity* Neurons / metabolism Oligodendroglia / metabolism* Solute Carrier Family 12, Member 2 / genetics Solute Carrier Family 12, Member 2 / metabolism* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC11202 RBRC05447 RBRC05446 RBRC05454 |