| RRC ID |
77577
|
| Author |
Yamazaki Y, Abe Y, Fujii S, Tanaka KF.
|
| Title |
Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
|
| Journal |
Nat Commun
|
| Abstract |
The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na+-K+-Cl- co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain.
|
| Volume |
12(1)
|
| Pages |
5146
|
| Published |
2021-8-26
|
| DOI |
10.1038/s41467-021-25488-5
|
| PII |
10.1038/s41467-021-25488-5
|
| PMID |
34446732
|
| PMC |
PMC8390751
|
| MeSH |
Animals
Axons / metabolism*
Brain / cytology
Brain / physiology*
Female
Learning
Male
Mice
Neuronal Plasticity*
Neurons / metabolism
Oligodendroglia / metabolism*
Solute Carrier Family 12, Member 2 / genetics
Solute Carrier Family 12, Member 2 / metabolism*
|
| IF |
12.121
|
| Resource |
| Mice |
RBRC11202
RBRC05447
RBRC05446
RBRC05454 |
