| RRC ID |
77839
|
| 著者 |
Kim HJ, Park JH, Kim HC, Kim CW, Kang I, Lee HK.
|
| タイトル |
Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169+ macrophages promoting an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we find that CD169+ macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells. CD169 expression on macrophages facilitates phagocytosis of apoptotic glioma cells and hence tumor-specific T cell responses. Depletion of CD169+ macrophages leads to functionally impaired antitumor lymphocytes and poorer survival of glioma-bearing mice. We show that NK-cell-derived IFN-γ is critical for the accumulation of blood monocyte-derived CD169+ macrophages in gliomas. Our work thus identifies a well-distinguished TAM subset promoting antitumor immunity against GBM, and identifies key factors that might shift the balance from immunosuppressive to anti-tumor TAM.
|
| 巻・号 |
13(1)
|
| ページ |
6211
|
| 公開日 |
2022-10-20
|
| DOI |
10.1038/s41467-022-34001-5
|
| PII |
10.1038/s41467-022-34001-5
|
| PMID |
36266311
|
| PMC |
PMC9585054
|
| MeSH |
Animals
Brain Neoplasms* / metabolism
Glioblastoma* / metabolism
Glioma* / pathology
Humans
Killer Cells, Natural
Macrophages / metabolism
Mice
Monocytes / metabolism
Tumor Microenvironment
|
| IF |
12.121
|
| リソース情報 |
| 実験動物マウス |
RBRC04395 |
