論文 - 詳細
| RRC ID | 77860 |
|---|---|
| 著者 | Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K. |
| タイトル | Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice. |
| ジャーナル | PLoS One |
| Abstract |
Whether fibril formation increases or decreases cytotoxicity remains unclear. Aggregation of human islet amyloid polypeptide (hIAPP), a pivotal regulator of glucose homeostasis, impairs the function and viability of pancreatic β cells. Evidence suggests that low-order oligomers of hIAPP are more toxic to β cells than fibril. However, it remains unclear whether non-fibril form of hIAPP specifically alters brain functions. This study produced fibril and non-fibril forms from a single hIAPP 8-20 peptide. The non-fibril form-injected mice showed changes in spontaneous motor activities, preference for location in the open field and social behavior. In contrast, the fibril-injected mice showed no changes in these behavioral tests. In line with the behavioral changes, the non-fibril form led to impaired neurite outgrowth of cultured neuron-like cells and the loss of neurons in the mouse hippocampus. These findings suggest that non-fibril form but not fibril form of hIAPP changes brain functions. |
| 巻・号 | 19(1) |
| ページ | e0296750 |
| 公開日 | 2024-1-1 |
| DOI | 10.1371/journal.pone.0296750 |
| PII | PONE-D-23-10509 |
| PMID | 38181010 |
| PMC | PMC10769099 |
| MeSH | Animals Brain Cytoskeleton Humans Islet Amyloid Polypeptide Mice Nervous System Physiological Phenomena* Peptide Hormones* |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |