| RRC ID |
77902
|
| 著者 |
Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M.
|
| タイトル |
Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis.
|
| ジャーナル |
Chem Pharm Bull (Tokyo)
|
| Abstract |
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia japonica, cultivated in Yunnan Province, China, showed inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the 1-butanol-soluble fraction, a new 28-nor-oleanane-type and three new oleanane-type triterpene saponins, sanchakasaponins A-D, were isolated together with four known triterpene saponins. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells and structure-activity relationships of the saponins were investigated.
|
| 巻・号 |
60(9)
|
| ページ |
1188-94
|
| 公開日 |
2012-1-1
|
| DOI |
10.1248/cpb.c12-00473
|
| PII |
DN/JST.JSTAGE/cpb/c12-00473
|
| PMID |
22976329
|
| MeSH |
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Camellia / chemistry*
Cell Line, Tumor
Flowers / chemistry
Melanins / antagonists & inhibitors*
Melanins / metabolism
Melanoma, Experimental / drug therapy*
Melanoma, Experimental / metabolism
Mice
Oleanolic Acid / chemistry*
Oleanolic Acid / isolation & purification
Oleanolic Acid / pharmacology*
Structure-Activity Relationship
|
| IF |
1.416
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
