| RRC ID |
78202
|
| 著者 |
Fujii K, Fujishima Y, Kita S, Kawada K, Fukuoka K, Sakaue TA, Okita T, Kawada-Horitani E, Nagao H, Fukuda S, Maeda N, Nishizawa H, Shimomura I.
|
| タイトル |
Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators.
|
| 巻・号 |
14(1)
|
| ページ |
3620
|
| 公開日 |
2024-2-13
|
| DOI |
10.1038/s41598-024-51935-6
|
| PII |
10.1038/s41598-024-51935-6
|
| PMID |
38351156
|
| PMC |
PMC10864391
|
| MeSH |
Adiponectin*
Animals
Cadherins*
Endothelial Cells
Extracellular Vesicles*
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Mice
Transcriptional Activation
|
| リソース情報 |
| ヒト・動物細胞 |
UV♀2(RCB1994) |
