論文 - 詳細
| RRC ID | 78237 |
|---|---|
| 著者 | Tanaka T, Takahashi K, Inoue Y, Endo N, Shimoda E, Ueno K, Ichiyanagi T, Ohta T, Ishihara A. |
| タイトル | Inhibition of melanoma cell proliferation by strobilurins isolated from mushrooms and their synthetic analogues. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Strobilurins A and X, isolated from Mucidula venosolamellata cluture extracts, demonstrated potent inhibition of human melanoma G-361 cell proliferation. Strobilurin X exhibited milder inhibitory effects on human fibroblast cells (NB1RGB) compared to strobilurin A. Additional strobilurin-related compounds were isolated from the other mushroom species. Oudemansins A and B displayed weaker activities on G-361 cells than strobilurins A and B, respectively, emphasizing the importance of a conjugated double-bond structure. Among isolated compounds, strobilurin G showed the lowest IC50 value for G-361 cells. Additional strobilurins bearing various substituents on the benzene ring were synthesised. Synthetic intermediates lacking the methyl β-methoxyacrylate group and a strobilurin analogue bearing modified β-methoxyacrylate moiety showed almost no inhibitory activity against G-361 cells. The introduction of long or bulky substituents at the 4'-position of the benzene ring of strobilurins enhanced the activity and selectivity, suggesting differential recognition of the benzene ring by G-361 and NB1RGB cells. |
| 公開日 | 2024-1-25 |
| DOI | 10.1093/bbb/zbae006 |
| PII | 7589712 |
| PMID | 38271595 |
| MeSH | Agaricales* Benzene Cell Proliferation Fungicides, Industrial* / chemistry Fungicides, Industrial* / pharmacology Humans Melanoma* Strobilurins / chemistry |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |
| きのこ | TUFC30333 TUFC12963 TUFC11891 |