論文 - 詳細
| RRC ID | 78514 |
|---|---|
| 著者 | Matsuzaki F, Ohshiro T, Ikeshima-Kataoka H, Izumi H. |
| タイトル | miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis. |
| ジャーナル | Development |
| Abstract |
When neuroblasts divide, prospero protein and mRNA segregate asymmetrically into the daughter neuroblast and sibling ganglion mother cell. miranda is known to localize prospero protein to the basal cell cortex of neuroblasts while the staufen RNA-binding protein mediates prospero mRNA localization. Here we show that miranda is required for asymmetric staufen localization in neuroblasts. Analyses using miranda mutants reveal that prospero and staufen interact with miranda under the same cell-cycle-dependent control. miranda thus acts to partition both prospero protein and mRNA. Furthermore, miranda localizes prospero and staufen to the basolateral cortex in dividing epithelial cells, which express the three proteins prior to neurogenesis. Our observations suggest that the epithelial cell and neuroblast (both of epithelial origin) share the same molecular machinery for creating cellular asymmetry. |
| 巻・号 | 125(20) |
| ページ | 4089-98 |
| 公開日 | 1998-10-1 |
| DOI | 10.1242/dev.125.20.4089 |
| PMID | 9735369 |
| MeSH | Alleles Animals Cell Cycle Proteins / genetics Cell Cycle Proteins / physiology* Cell Polarity / genetics Drosophila Proteins* Drosophila melanogaster / cytology Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Ectoderm / cytology Epithelial Cells / cytology Epithelial Cells / metabolism Ganglia, Invertebrate / cytology Genes, Insect Immunohistochemistry In Situ Hybridization Mitosis* / genetics Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neurons / cytology Neurons / metabolism* Nuclear Proteins / genetics Nuclear Proteins / metabolism* RNA-Binding Proteins / metabolism* Sequence Deletion Stem Cells Transcription Factors* |
| リソース情報 | |
| ショウジョウバエ | DGRC#119106 |