論文 - 詳細
| RRC ID | 78516 |
|---|---|
| 著者 | Hirata J, Nakagoshi H, Nabeshima Y, Matsuzaki F. |
| タイトル | Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. |
| ジャーナル | Nature |
| Abstract |
Asymmetric divisions that produce two distinct cells play fundamental roles in generating different cell types during development. In the Drosophila central nervous system, neural stem cells called neuroblasts divide unequally into another neuroblast and a ganglion mother cell which is subsequently cleaved into neurons. Correct gene expression of ganglion mother cells requires the transcription factor Prospero. Here we demonstrate the asymmetric segregation of Prospero on neuroblast division. Prospero synthesized in neuroblasts is retained in the cytoplasm and at mitosis is exclusively partitioned to ganglion mother cells, in which it is translocated to the nucleus. Differential segregation of Prospero was also found in the endoderm. We have identified a region in Prospero that is responsible for this event. The region shares a common motif with Numb, which also shows unequal segregation. We propose that asymmetric segregation of transcription factors is an intrinsic mechanism for establishing asymmetry in gene expression between sibling cells. |
| 巻・号 | 377(6550) |
| ページ | 627-30 |
| 公開日 | 1995-10-19 |
| DOI | 10.1038/377627a0 |
| PMID | 7566173 |
| MeSH | Amino Acid Sequence Animals Binding Sites Cell Cycle / physiology Cell Division / physiology* Cell Nucleus / metabolism Cytoplasm / metabolism Drosophila / cytology Drosophila / embryology* Drosophila Proteins* Escherichia coli / genetics Ganglia, Invertebrate / cytology Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Molecular Sequence Data Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neurons / cytology Nuclear Proteins / genetics Nuclear Proteins / metabolism* RNA, Messenger / metabolism Recombinant Fusion Proteins / metabolism Transcription Factors* beta-Galactosidase / genetics |
| IF | 42.779 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119121 |