論文 - 詳細
| RRC ID | 78646 |
|---|---|
| 著者 | Katase N, Kudo K, Ogawa K, Sakamoto Y, Nishimatsu SI, Yamauchi A, Fujita S. |
| タイトル | DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer. |
| ジャーナル | Oral Dis |
| Abstract |
OBJECTIVE:We previously reported that dickkopf WNT signaling inhibitor 3 (DKK3) would modulate malignant potential of oral squamous cell carcinoma (OSCC) via activating Akt. Recently, cytoskeleton associated protein 4 (CKAP4) functions as receptor of DKK3, which activates Akt in esophageal squamous cell carcinoma, but its expression and function in OSCC were unclear. METHODS:We studied DKK3 and CKAP4 protein expression in OSCC tissue and investigated the correlation between protein expression and clinical data. We also investigated whether antibodies (Ab) for DKK3 or CKAP4 could suppress malignant potential of the cancer cells. RESULTS:DKK3/CKAP4 protein expression was observed in majority of OSCC cases and was associated with significantly higher T-stage and TNM stage. Multivariate analysis revealed that DKK3 and CKAP4 were independent prognostic biomarkers for overall survival (OS) and disease-free survival (DFS), respectively. Survival analyses revealed that DKK3-positive cases and CKAP4-positive cases showed significantly shorter OS and DFS, respectively, and that DKK3/CKAP4 double-negative cases showed significantly favorable prognosis. Both anti-DKK3Ab and anti-CKAP4Ab could suppress cancer cell proliferation, migration, and invasion. CONCLUSION:DKK3/CKAP4 axis is thought to be important in OSCC, and it would be a promising therapeutic target. |
| 巻・号 | 29(8) |
| ページ | 3193-3204 |
| 公開日 | 2023-11-1 |
| DOI | 10.1111/odi.14277 |
| PMID | 35708905 |
| MeSH | Adaptor Proteins, Signal Transducing Carcinoma, Squamous Cell* / pathology Cell Line, Tumor Cell Proliferation Esophageal Neoplasms* Esophageal Squamous Cell Carcinoma* Head and Neck Neoplasms* Humans Intercellular Signaling Peptides and Proteins / metabolism Membrane Proteins / metabolism Mouth Neoplasms* Prognosis Proto-Oncogene Proteins c-akt / metabolism Squamous Cell Carcinoma of Head and Neck |
| リソース情報 | |
| ヒト・動物細胞 | HSC-3(RCB1975) SCCKN(RCB0441) SAS(RCB1974) |