| RRC ID |
78680
|
| 著者 |
Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Nishibeppu K, Kamiya H, Arakawa H, Ishida R, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Fujiwara H, Otsuji E.
|
| タイトル |
Plasma miR-1254 as a predictive biomarker of chemosensitivity and a target of nucleic acid therapy in esophageal cancer.
|
| ジャーナル |
Cancer Sci
|
| Abstract |
This study investigated novel tumor suppressor microRNAs (miRNAs) that decrease in plasma and predict chemosensitivity to neoadjuvant chemotherapy (NAC) for esophageal squamous cell carcinoma (ESCC) and revealed their usefulness as novel therapeutic agents. We selected four miRNA candidates (miR-323, 345, 409, and 1254) based on the microRNA microarray comparing pre-treatment plasma levels in ESCC patients with high and low histopathological responses to NAC and an NCBI database review. Among these miRNA candidates, miR-1254 was more highly elevated in pre-treatment plasma of ESCC patients with a high histopathological response than in those with a low histopathological response (P = 0.0021, area under the receiver-operating characteristic curve 0.7621). High plasma miR-1254 levels tended to correlate with the absence of venous invasion (P = 0.0710) and were an independent factor predicting a higher response to chemotherapy (P = 0.0022, odds ratio 7.86) and better prognosis (P = 0.0235, hazard ratio 0.23). Overexpressing miR-1254 in ESCC cells significantly enhanced chemosensitivity to cisplatin through the transcriptional regulation of ABCC1 in vitro. Moreover, increased plasma miR-1254 levels by subcutaneous injection significantly improved responses to cisplatin in mice. Plasma miR-1254 might be a useful biomarker for predicting responses to NAC, and the restoration of plasma miR-1254 levels might improve chemosensitivity in ESCC.
|
| 巻・号 |
114(7)
|
| ページ |
3027-3040
|
| 公開日 |
2023-7-1
|
| DOI |
10.1111/cas.15830
|
| PMID |
37190912
|
| PMC |
PMC10323105
|
| MeSH |
Animals
Biomarkers, Tumor / genetics
Carcinoma, Squamous Cell* / drug therapy
Carcinoma, Squamous Cell* / genetics
Cell Line, Tumor
Cisplatin
Esophageal Neoplasms* / drug therapy
Esophageal Neoplasms* / genetics
Esophageal Neoplasms* / pathology
Esophageal Squamous Cell Carcinoma* / drug therapy
Esophageal Squamous Cell Carcinoma* / genetics
Gene Expression Regulation, Neoplastic
Mice
MicroRNAs* / genetics
Prognosis
|
| リソース情報 |
| ヒト・動物細胞 |
TE-5(RCB1949)
TE-8(RCB2098)
TE-11(RCB2100)
TE-15(RCB1951) |
