論文 - 詳細
| RRC ID | 78767 |
|---|---|
| 著者 | Omori K, Otani S, Date Y, Ueno T, Ito T, Umeda M, Ito K. |
| タイトル | C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development. |
| ジャーナル | Oncogene |
| Abstract |
Osteosarcoma (OS) is characterized by TP53 mutations in humans. In mice, loss of p53 triggers OS development, and osteoprogenitor-specific p53-deleted mice are widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms underlying the initiation or progression of OS following or parallel to p53 inactivation remain largely unknown. Here, we examined the role of transcription factors involved in adipogenesis (adipo-TFs) in p53-deficient OS and identified a novel tumor suppressive molecular mechanism mediated by C/ebpα. C/ebpα specifically interacts with Runx3, a p53 deficiency-dependent oncogene, and, in the same manner as p53, decreases the activity of the oncogenic axis of OS, Runx3-Myc, by inhibiting Runx3 DNA binding. The identification of a novel molecular role for C/ebpα in p53-deficient osteosarcomagenesis underscores the importance of the Runx-Myc oncogenic axis as a therapeutic target for OS. |
| 巻・号 | 42(33) |
| ページ | 2485-2494 |
| 公開日 | 2023-8-1 |
| DOI | 10.1038/s41388-023-02761-z |
| PII | 10.1038/s41388-023-02761-z |
| PMID | 37402881 |
| MeSH | Animals Bone Neoplasms* / genetics CCAAT-Enhancer-Binding Protein-alpha* / genetics CCAAT-Enhancer-Binding Protein-alpha* / metabolism Core Binding Factor Alpha 3 Subunit / genetics Core Binding Factor Alpha 3 Subunit / metabolism Humans Mice Osteosarcoma* / genetics Proto-Oncogene Proteins c-myc / genetics Proto-Oncogene Proteins c-myc / metabolism Transcription Factors / metabolism Tumor Suppressor Protein p53 / metabolism |
| IF | 7.971 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB224) HS-Os-1(RCB2229) |