論文 - 詳細
| RRC ID | 78782 |
|---|---|
| 著者 | Sakamoto K, Uchiyama K, Iwasaki T, Inaba H, Matsuura K. |
| タイトル | An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells. |
| ジャーナル | J Mater Chem B |
| Abstract |
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells. |
| 巻・号 | 11(26) |
| ページ | 6053-6059 |
| 公開日 | 2023-7-5 |
| DOI | 10.1039/d3tb00169e |
| PMID | 37310262 |
| MeSH | Aptamers, Nucleotide* Burkitt Lymphoma* / drug therapy Capsid Doxorubicin / pharmacology Humans Peptides |
| IF | 5.344 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |