Reference - Detail
| RRC ID | 79057 |
|---|---|
| Author | Nguyen TD, Miyatake Y, Yoshida T, Kawahara H, Hanayama R. |
| Title | Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia. |
| Journal | Int J Cancer |
| Abstract |
Cancer-associated cachexia (CAC) is a common syndrome in cancer patients and is characterized by loss of body weight accompanied by the atrophy of fat and skeletal muscle. Metabolic changes are a critical factor in CAC; however, the mechanisms through which tumors inhibit adipogenesis and promote lipolysis are poorly understood. To clarify these mechanisms, we investigated adipogenesis-limiting factors released by tumors in a cell culture system. We identified proliferin-1 (PLF-1), a member of the growth hormone/prolactin gene family, as a key factor secreted from certain tumors that inhibited preadipocyte maturation and promoted the lipolysis of mature adipocytes. Importantly, mice transplanted with PLF-1-depleted tumor cells were protected from fat loss due to CAC. These data show that tumor-secreted PLF-1 plays an essential role in impaired adipogenesis and accelerated lipolysis and is a potential therapeutic target against CAC. |
| Volume | 148(8) |
| Pages | 1982-1992 |
| Published | 2021-4-15 |
| DOI | 10.1002/ijc.33418 |
| PMID | 33252827 |
| MeSH | Adipocytes / cytology Adipocytes / metabolism Adipogenesis / genetics* Animals Body Weight / genetics Cachexia / genetics* Cachexia / metabolism Cell Differentiation / genetics Cell Line, Tumor Cells, Cultured Gene Expression Regulation, Neoplastic Lipolysis / genetics* Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Neoplasms / genetics* Neoplasms / metabolism Neoplasms / pathology Prolactin / genetics* Prolactin / metabolism |
| IF | 5.145 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | FM3A(RCB0086) Ehrlich(RCB0142) EL4(RCB1641) |