論文 - 詳細
| RRC ID | 79124 |
|---|---|
| 著者 | Miyadai M, Takada H, Shiraishi A, Kimura T, Watakabe I, Kobayashi H, Nagao Y, Naruse K, Higashijima SI, Shimizu T, Kelsh RN, Hibi M, Hashimoto H. |
| タイトル | A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish. |
| ジャーナル | Development |
| Abstract |
Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network for melanocytes (their only pigment cell type) contains three transcription factors, Sox10, Pax3 and Mitf, with the latter considered a master regulator of melanocyte development. In teleosts, which have three to four pigment cell types (melanophores, iridophores and xanthophores, plus leucophores e.g. in medaka), gene regulatory networks governing fate specification are poorly understood, although Mitf function is considered conserved. Here, we show that the regulatory relationships between Sox10, Pax3 and Mitf are conserved in zebrafish, but the role for Mitf is more complex than previously emphasized, affecting xanthophore development too. Similarly, medaka Mitf is necessary for melanophore, xanthophore and leucophore formation. Furthermore, expression patterns and mutant phenotypes of pax3 and pax7 suggest that Pax3 and Pax7 act sequentially, activating mitf expression. Pax7 modulates Mitf function, driving co-expressing cells to differentiate as xanthophores and leucophores rather than melanophores. We propose that pigment cell fate specification should be considered to result from the combinatorial activity of Mitf with other transcription factors. |
| 巻・号 | 150(19) |
| 公開日 | 2023-10-1 |
| DOI | 10.1242/dev.202114 |
| PII | 332746 |
| PMID | 37823232 |
| PMC | PMC10617610 |
| MeSH | Animals Gene Regulatory Networks Mammals / genetics Melanocytes / metabolism Mutation Neural Crest / metabolism Oryzias* / genetics Oryzias* / metabolism SOXE Transcription Factors / genetics SOXE Transcription Factors / metabolism Zebrafish* / genetics Zebrafish* / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 5.611 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | lf-2 (MT77) Nagoya (WS3) d-rR/Tokyo (MT837) |