論文 - 詳細
| RRC ID | 79171 |
|---|---|
| 著者 | Dsilva P, Pai P, Shetty MG, Babitha KS. |
| タイトル | The role of histone deacetylases in embryonic development. |
| ジャーナル | Mol Reprod Dev |
| Abstract |
The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article. |
| 巻・号 | 90(1) |
| ページ | 14-26 |
| 公開日 | 2023-1-1 |
| DOI | 10.1002/mrd.23659 |
| PMID | 36534913 |
| MeSH | Acetylation Chromatin Embryonic Development Histone Deacetylase Inhibitors / pharmacology Histone Deacetylases* / metabolism Histones* / metabolism |
| IF | 2.823 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | RIKEN WT |