Reference - Detail
| RRC ID | 79260 |
|---|---|
| Author | Maekawa Y, Matsui K, Okamoto K, Shimasaki T, Ohtsuka H, Tani M, Ihara K, Aiba H. |
| Title | Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe. |
| Journal | Mol Genet Genomics |
| Abstract |
To understand the lifespan of higher organisms, including humans, it is important to understand lifespan at the cellular level as a prerequisite. So, fission yeast is a good model organism for the study of lifespan. To identify the novel factors involved in longevity, we are conducting a large-scale screening of long-lived mutant strains that extend chronological lifespan (cell survival in the stationary phase) using fission yeast. One of the newly acquired long-lived mutant strains (No.98 mutant) was selected for analysis and found that the long-lived phenotype was due to a missense mutation (92Phe → Ile) in the plb1+ gene. plb1+ gene in fission yeast is a nonessential gene encoding a homolog of phospholipase B, but its functions under normal growth conditions, as well as phospholipase B activity, remain unresolved. Our analysis of the No.98 mutant revealed that the plb1 mutation reduces the integrity of the cellular membrane and cell wall and activates Sty1 via phosphorylation. |
| Volume | 299(1) |
| Pages | 20 |
| Published | 2024-2-29 |
| DOI | 10.1007/s00438-024-02107-8 |
| PII | 10.1007/s00438-024-02107-8 |
| PMID | 38424265 |
| MeSH | Gene Expression Regulation, Fungal Humans Longevity / genetics Lysophospholipase / genetics Lysophospholipase / metabolism Mutation Schizosaccharomyces* / metabolism Schizosaccharomyces pombe Proteins* / genetics Schizosaccharomyces pombe Proteins* / metabolism |
| IF | 2.797 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |