論文 - 詳細
| RRC ID | 79401 |
|---|---|
| 著者 | Wu X, Zhou L, Ye C, Zha Z, Li C, Feng C, Zhang Y, Jin Q, Pan J. |
| タイトル | Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity. |
| ジャーナル | Cell Rep |
| Abstract |
Cyclic di-guanosine monophosphate (c-di-GMP) is a unique bacterial second messenger but is hijacked by host cells during bacterial infection as a pathogen-associated molecular pattern (PAMP) to trigger STING-dependent immune responses. Here, we show that upon infection, VopY, an effector of Vibrio parahaemolyticus, is injected into host cells by type III secretion system 2 (T3SS2), a secretion system unique to its pathogenic strains and indispensable for enterotoxicity. VopY is an EAL-domain-containing phosphodiesterase and is capable of hydrolyzing c-di-GMP. VopY expression in host cells prevents the activation of STING and STING-dependent downstream signaling triggered by c-di-GMP and, consequently, suppresses type I interferon immune responses. The presence of VopY in V. parahaemolyticus enables it to cause both T3SS2-dependent enterotoxicity and cytotoxicity. These findings uncover the destruction of self-derived PAMPs by injecting specific effectors to suppress PAMP-triggered immune responses as a unique strategy for bacterial pathogens to subvert immunity and cause disease. |
| 巻・号 | 42(10) |
| ページ | 113261 |
| 公開日 | 2023-10-31 |
| DOI | 10.1016/j.celrep.2023.113261 |
| PII | S2211-1247(23)01273-1 |
| PMID | 37847589 |
| MeSH | Bacterial Proteins / metabolism Innate Immunity Recognition Type III Secretion Systems / metabolism Vibrio parahaemolyticus* / metabolism Virulence |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原細菌 | JNBP_30766 |