論文 - 詳細
| RRC ID | 80054 |
|---|---|
| 著者 | Atsushi Noritake, Taihei Ninomiya, Kenta Kobayashi, Masaki Isoda |
| タイトル | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| ジャーナル | Nature Communications |
| Abstract |
The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts. |
| 巻・号 | 14 |
| 公開日 | 2023-7-20 |
| DOI | 10.1038/s41467-023-40143-x |
| PMID | 37474519 |
| PMC | PMC10359292 |
| MeSH | Animals Hypothalamic Area, Lateral Hypothalamus Macaca* Male Prefrontal Cortex Reward* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 54 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |