論文 - 詳細
| RRC ID | 80098 |
|---|---|
| 著者 | Tachibana K, Nakamura Y, Do TL, Kihara T, Kawada H, Yamamoto N, Ando K. |
| タイトル | Mutations in the SARS-cov-2 spike proteins affected the ACE2-binding affinity during the development of omicron pandemic variants. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Mutations in SARS-CoV-2 caused multiple waves of pandemics. To identify the function of such mutations, we investigated the binding affinity of the S protein with its receptor, ACE2. Omicron BA.1 showed significantly lower binding affinity with human ACE2 than prototype SARS-CoV-2 and Alpha strain, indicating that pre-Omicron to Omicron transition was not mediated by increasing the ACE2-binding affinity. Meanwhile, the later Omicron variants, BA.5 and XBB.1.5, showed significantly higher ACE2-binding affinity, suggesting that the increased ACE2-binding could be involved in the variant transition within Omicron strains. Furthermore, Alpha and Omicron variants, but not prototype SARS-CoV-2, bound mouse ACE2, which lead to a hypothesis that early Omicron strains evolved from Alpha strain by acquiring multiple mutations in mice. |
| 巻・号 | 719 |
| ページ | 150120 |
| 公開日 | 2024-5-14 |
| DOI | 10.1016/j.bbrc.2024.150120 |
| PII | S0006-291X(24)00656-9 |
| PMID | 38759524 |
| MeSH | Angiotensin-Converting Enzyme 2* / genetics Angiotensin-Converting Enzyme 2* / metabolism Animals COVID-19* / metabolism COVID-19* / virology Humans Mice Mutation* Pandemics Protein Binding* SARS-CoV-2* / genetics SARS-CoV-2* / metabolism Spike Glycoprotein, Coronavirus* / chemistry Spike Glycoprotein, Coronavirus* / genetics Spike Glycoprotein, Coronavirus* / metabolism |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |