RRC ID 80175
Author Hirayama T, Miyazaki T, Sumiyoshi M, Ito Y, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Yamamoto K, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Kohno S, Mukae H.
Title Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.
Journal Antimicrob Agents Chemother
Abstract Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro.
Volume 67(4)
Pages e0124322
Published 2023-4-18
DOI 10.1128/aac.01243-22
PMID 36920237
PMC PMC10112215
MeSH Animals Antifungal Agents / pharmacology Antifungal Agents / therapeutic use Candida auris* Drug Resistance, Fungal / genetics Echinocandins* / genetics Echinocandins* / pharmacology Fungal Proteins* / genetics Gastrointestinal Tract Glucosyltransferases* Micafungin / pharmacology Mice Microbial Sensitivity Tests Mutation / genetics
Resource
General Microbes JCM 15448