論文 - 詳細
| RRC ID | 80175 |
|---|---|
| 著者 | Hirayama T, Miyazaki T, Sumiyoshi M, Ito Y, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Yamamoto K, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Kohno S, Mukae H. |
| タイトル | Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro. |
| 巻・号 | 67(4) |
| ページ | e0124322 |
| 公開日 | 2023-4-18 |
| DOI | 10.1128/aac.01243-22 |
| PMID | 36920237 |
| PMC | PMC10112215 |
| MeSH | Animals Antifungal Agents / pharmacology Antifungal Agents / therapeutic use Candida auris* Drug Resistance, Fungal / genetics Echinocandins* / genetics Echinocandins* / pharmacology Fungal Proteins* / genetics Gastrointestinal Tract Glucosyltransferases* Micafungin / pharmacology Mice Microbial Sensitivity Tests Mutation / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 15448 |