Reference - Detail
RRC ID | 80175 |
---|---|
Author | Hirayama T, Miyazaki T, Sumiyoshi M, Ito Y, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Yamamoto K, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Kohno S, Mukae H. |
Title | Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations. |
Journal | Antimicrob Agents Chemother |
Abstract |
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro. |
Volume | 67(4) |
Pages | e0124322 |
Published | 2023-4-18 |
DOI | 10.1128/aac.01243-22 |
PMID | 36920237 |
PMC | PMC10112215 |
MeSH | Animals Antifungal Agents / pharmacology Antifungal Agents / therapeutic use Candida auris* Drug Resistance, Fungal / genetics Echinocandins* / genetics Echinocandins* / pharmacology Fungal Proteins* / genetics Gastrointestinal Tract Glucosyltransferases* Micafungin / pharmacology Mice Microbial Sensitivity Tests Mutation / genetics |
Resource | |
General Microbes | JCM 15448 |