Reference - Detail
| RRC ID | 80505 |
|---|---|
| Author | Kikuchi Y, Kawashima M, Iwatsuki M, Kimishima A, Tsutsumi H, Asami Y, Inahashi Y. |
| Title | Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Limited microbial genera such as Streptomyces have served as sources of natural products (NPs), whereas most others have been less investigated. The vast accumulation of genomic data available in the NCBI database enables us to bioinformatically estimate the ability of other microbial groups to produce NPs. We analyzed 21,052 complete bacterial genome sequences using antiSMASH and compared the average numbers of biosynthetic gene clusters (BGCs) related to polyketides, non-ribosomal peptides, and/or terpenes biosynthesis at the genus level. Our bioinformatic analyses showed that Tumebacillus has 5-15 BGCs and is a promising NP producer. We searched for NPs from the culture broth of Tumebacillus permanentifrigoris JCM 14557T and found two novel compounds (tumebacin with anti-Bacillus activity and tumepyrazine) and identified two known compounds. Our results highlight the diversity of sources of NPs awaiting discovery. |
| Volume | 76(6) |
| Pages | 316-323 |
| Published | 2023-6-1 |
| DOI | 10.1038/s41429-023-00609-y |
| PII | 10.1038/s41429-023-00609-y |
| PMID | 36991235 |
| MeSH | Bacteria / genetics Biological Products* Computational Biology Genomics / methods Multigene Family |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 14557 |