RRC ID 80643
Author Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I.
Title Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides.
Journal Gut Microbes
Abstract Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides-produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS.
Volume 15(1)
Pages 2161271
Published 2023-1-1
DOI 10.1080/19490976.2022.2161271
PMID 36604628
PMC PMC9828693
MeSH Bacteria Fermentation Gastrointestinal Microbiome* Lactobacillales* / metabolism Leuconostoc mesenteroides* Prebiotics Probiotics*
Resource
General Microbes