RRC ID 80715
Author Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H.
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal J Bacteriol
Abstract Glutathione protects cells and organisms from oxygen species and peroxides and is indispensable for aerobically living organisms. Moreover, it acts against xenobiotics and drugs by the formation and excretion of glutathione S conjugates. In this study, we show that the yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a glutathione transporter with the ATP-binding cassette. The transporter imports extracellular glutathione into the cytoplasm in an ATP-dependent manner. This transporter, along with gamma-glutamyltranspeptidase, has an important role in E. coli growth with glutathione as a sole sulfur source.
Volume 187(17)
Pages 5861-7
Published 2005-9-1
DOI 10.1128/JB.187.17.5861-5867.2005
PII 187/17/5861
PMID 16109926
PMC PMC1196167
MeSH ATP-Binding Cassette Transporters / genetics* ATP-Binding Cassette Transporters / metabolism* Base Sequence Cytoplasm / metabolism DNA Primers Escherichia coli K12 / genetics* Escherichia coli K12 / metabolism* Glutamic Acid / metabolism* Kinetics Molecular Sequence Data Mutagenesis Plasmids Restriction Mapping
IF 3.006
Prokaryotes E. coli ME9995 ME9996