論文 - 詳細
| RRC ID | 80750 |
|---|---|
| 著者 | Wang Z, Zou L, Zhang Y, Zhu M, Zhang S, Wu D, Lan J, Zang X, Wang Q, Zhang H, Wu Z, Zhu H, Chen D. |
| タイトル | ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from a genetic screen of the C. elegans acyl-CoA synthetase family. ACS-20 functions in the epidermis during development to regulate dietary restriction-induced longevity. Functional transcriptomics studies reveal that elevated expression of PTR-8/Patched is responsible for the proteostasis and lifespan defects of acs-20. Furthermore, the conserved NHR-23 nuclear receptor serves as a transcriptional repressor of ptr-8 and a key regulator of dietary restriction-induced longevity. Mechanistically, a specific region in the ptr-8 promoter plays a key role in mediating the transcription regulation and lifespan extension under dietary restriction. Altogether, these findings identify a highly conserved lipid metabolism enzyme as a key mediator of dietary restriction-induced lifespan and healthspan extension and reveal the downstream transcriptional regulation mechanisms. |
| 巻・号 | 14(1) |
| ページ | 7683 |
| 公開日 | 2023-11-24 |
| DOI | 10.1038/s41467-023-43613-4 |
| PII | 10.1038/s41467-023-43613-4 |
| PMID | 38001113 |
| PMC | PMC10673863 |
| MeSH | Aging / genetics Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Caloric Restriction Carrier Proteins / metabolism Longevity / physiology Transcription Factors / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3232 |