論文 - 詳細
| RRC ID | 80788 |
|---|---|
| 著者 | Dag U, Nwabudike I, Kang D, Gomes MA, Kim J, Atanas AA, Bueno E, Estrem C, Pugliese S, Wang Z, Towlson E, Flavell SW. |
| タイトル | Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale. |
| ジャーナル | Cell |
| Abstract |
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse receptors across the brain to modulate global activity and behavior is unknown. Here, we examine how serotonin release in C. elegans alters brain-wide activity to induce foraging behaviors, like slow locomotion and increased feeding. Comprehensive genetic analyses identify three core serotonin receptors (MOD-1, SER-4, and LGC-50) that induce slow locomotion upon serotonin release and others (SER-1, SER-5, and SER-7) that interact with them to modulate this behavior. SER-4 induces behavioral responses to sudden increases in serotonin release, whereas MOD-1 induces responses to persistent release. Whole-brain imaging reveals widespread serotonin-associated brain dynamics, spanning many behavioral networks. We map all sites of serotonin receptor expression in the connectome, which, together with synaptic connectivity, helps predict which neurons show serotonin-associated activity. These results reveal how serotonin acts at defined sites across a connectome to modulate brain-wide activity and behavior. |
| 巻・号 | 186(12) |
| ページ | 2574-2592.e20 |
| 公開日 | 2023-6-8 |
| DOI | 10.1016/j.cell.2023.04.023 |
| PII | S0092-8674(23)00419-1 |
| PMID | 37192620 |
| PMC | PMC10484565 |
| MeSH | Animals Behavior, Animal / physiology Brain / metabolism Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Receptors, Serotonin / genetics Receptors, Serotonin / metabolism Serotonin / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 72 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm2647 tm1325 |