論文 - 詳細
| RRC ID | 80836 |
|---|---|
| 著者 | Abay-Nørgaard S, Tapia MC, Zeijdner M, Kim JH, Won KJ, Porse B, Salcini AE. |
| タイトル | Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. |
| ジャーナル | Life Sci Alliance |
| Abstract |
Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis. |
| 巻・号 | 6(8) |
| 公開日 | 2023-8-1 |
| DOI | 10.26508/lsa.202301970 |
| PII | 6/8/e202301970 |
| PMID | 37225426 |
| PMC | PMC10209521 |
| MeSH | Animals Caenorhabditis elegans* / genetics Epigenome* Epigenomics Homeostasis / genetics Methylation |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm1905 tm1200 |