論文 - 詳細
| RRC ID | 80846 |
|---|---|
| 著者 | Teuscher AC, Statzer C, Goyala A, Domenig SA, Schoen I, Hess M, Hofer AM, Fossati A, Vogel V, Goksel O, Aebersold R, Ewald CY. |
| タイトル | Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM, to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1 across tissues. Our results provide in-vivo evidence that coordinated ECM remodeling through mechanotransduction is required and sufficient to promote longevity, offering potential avenues for interventions targeting ECM dynamics. |
| 巻・号 | 15(1) |
| ページ | 276 |
| 公開日 | 2024-1-4 |
| DOI | 10.1038/s41467-023-44409-2 |
| PII | 10.1038/s41467-023-44409-2 |
| PMID | 38177158 |
| PMC | PMC10766642 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Collagen / metabolism Extracellular Matrix / metabolism Homeostasis Longevity* / physiology Mechanotransduction, Cellular Transcription Factors / genetics Transcription Factors / metabolism YAP-Signaling Proteins |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 62 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm8818 tm1416 tm6673 tm548 tm385 tm1092 |