論文 - 詳細
| RRC ID | 80873 |
|---|---|
| 著者 | Ray S, Gurung P, Manning RS, Kravchuk AA, Singhvi A. |
| タイトル | Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing. |
| ジャーナル | Cell Rep |
| Abstract |
Glia interact with multiple neurons, but it is unclear whether their interactions with each neuron are different. Our interrogation at single-cell resolution reveals that a single glial cell exhibits specificity in its interactions with different contacting neurons. Briefly, C. elegans amphid sheath (AMsh) glia apical-like domains contact 12 neuron-endings. At these ad-neuronal membranes, AMsh glia localize the K/Cl transporter KCC-3 to a microdomain exclusively around the thermosensory AFD neuron to regulate its properties. Glial KCC-3 is transported to ad-neuronal regions, where distal cilia of non-AFD glia-associated chemosensory neurons constrain it to a microdomain at AFD-contacting glial membranes. Aberrant KCC-3 localization impacts both thermosensory (AFD) and chemosensory (non-AFD) neuron properties. Thus, neurons can interact non-synaptically through a shared glial cell by regulating microdomain localization of its cues. As AMsh and glia across species compartmentalize multiple cues like KCC-3, we posit that this may be a broadly conserved glial mechanism that modulates information processing across multimodal circuits. |
| 巻・号 | 43(3) |
| ページ | 113844 |
| 公開日 | 2024-3-26 |
| DOI | 10.1016/j.celrep.2024.113844 |
| PII | S2211-1247(24)00172-4 |
| PMID | 38421867 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Cilia / metabolism Neuroglia / metabolism Neurons / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 37 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm487 |