論文 - 詳細
| RRC ID | 80882 |
|---|---|
| 著者 | De-Souza EA, Thompson MA, Taylor RC. |
| タイトル | Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. |
| ジャーナル | Nat Aging |
| Abstract |
Animals rely on chemosensory cues to survive in pathogen-rich environments. In Caenorhabditis elegans, pathogenic bacteria trigger aversive behaviors through neuronal perception and activate molecular defenses throughout the animal. This suggests that neurons can coordinate the activation of organism-wide defensive responses upon pathogen perception. In this study, we found that exposure to volatile pathogen-associated compounds induces activation of the endoplasmic reticulum unfolded protein response (UPRER) in peripheral tissues after xbp-1 splicing in neurons. This odorant-induced UPRER activation is dependent upon DAF-7/transforming growth factor beta (TGF-β) signaling and leads to extended lifespan and enhanced clearance of toxic proteins. Notably, rescue of the DAF-1 TGF-β receptor in RIM/RIC interneurons is sufficient to significantly recover UPRER activation upon 1-undecene exposure. Our data suggest that the cell non-autonomous UPRER rewires organismal proteostasis in response to pathogen detection, pre-empting proteotoxic stress. Thus, chemosensation of particular odors may be a route to manipulation of stress responses and longevity. |
| 巻・号 | 3(8) |
| ページ | 938-947 |
| 公開日 | 2023-8-1 |
| DOI | 10.1038/s43587-023-00467-1 |
| PII | 10.1038/s43587-023-00467-1 |
| PMID | 37500972 |
| PMC | PMC10432268 |
| MeSH | Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Longevity* Transforming Growth Factor beta / metabolism Unfolded Protein Response |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 58 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm373 |