| RRC ID |
80882
|
| 著者 |
De-Souza EA, Thompson MA, Taylor RC.
|
| タイトル |
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation.
|
| ジャーナル |
Nat Aging
|
| Abstract |
Animals rely on chemosensory cues to survive in pathogen-rich environments. In Caenorhabditis elegans, pathogenic bacteria trigger aversive behaviors through neuronal perception and activate molecular defenses throughout the animal. This suggests that neurons can coordinate the activation of organism-wide defensive responses upon pathogen perception. In this study, we found that exposure to volatile pathogen-associated compounds induces activation of the endoplasmic reticulum unfolded protein response (UPRER) in peripheral tissues after xbp-1 splicing in neurons. This odorant-induced UPRER activation is dependent upon DAF-7/transforming growth factor beta (TGF-β) signaling and leads to extended lifespan and enhanced clearance of toxic proteins. Notably, rescue of the DAF-1 TGF-β receptor in RIM/RIC interneurons is sufficient to significantly recover UPRER activation upon 1-undecene exposure. Our data suggest that the cell non-autonomous UPRER rewires organismal proteostasis in response to pathogen detection, pre-empting proteotoxic stress. Thus, chemosensation of particular odors may be a route to manipulation of stress responses and longevity.
|
| 巻・号 |
3(8)
|
| ページ |
938-947
|
| 公開日 |
2023-8-1
|
| DOI |
10.1038/s43587-023-00467-1
|
| PII |
10.1038/s43587-023-00467-1
|
| PMID |
37500972
|
| PMC |
PMC10432268
|
| MeSH |
Animals
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins* / genetics
Longevity*
Transforming Growth Factor beta / metabolism
Unfolded Protein Response
|
| リソース情報 |
| 線虫 |
tm373 |
