RRC ID 80956
Author Villalobos TV, Ghosh B, DeLeo KR, Alam S, Ricaurte-Perez C, Wang A, Mercola BM, Butsch TJ, Ramos CD, Das S, Eymard ED, Bohnert KA, Johnson AE.
Title Tubular lysosome induction couples animal starvation to healthy aging.
Journal Nat Aging
Abstract Dietary restriction promotes longevity in several species via autophagy activation. However, changes to lysosomes underlying this effect remain unclear. Here using the nematode Caenorhabditis elegans, we show that the induction of autophagic tubular lysosomes (TLs), which occurs upon dietary restriction or mechanistic target of rapamycin inhibition, is a critical event linking reduced food intake to lifespan extension. We find that starvation induces TLs not only in affected individuals but also in well-fed descendants, and the presence of gut TLs in well-fed progeny is predictive of enhanced lifespan. Furthermore, we demonstrate that expression of Drosophila small VCP-interacting protein, a TL activator in flies, artificially induces TLs in well-fed worms and improves C. elegans health in old age. These findings identify TLs as a new class of lysosomes that couples starvation to healthy aging.
Volume 3(9)
Pages 1091-1106
Published 2023-9-1
DOI 10.1038/s43587-023-00470-6
PII 10.1038/s43587-023-00470-6
PMID 37580394
PMC PMC10501908
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins* / genetics Healthy Aging* Lysosomes / metabolism Starvation* / metabolism
Resource
C.elegans tm1200