Reference - Detail
| RRC ID | 81241 |
|---|---|
| Author | Lee D, Jo MG, Min KY, Choi MY, Kim YM, Kim HS, Choi WS. |
| Title | IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. |
| Journal | Sci Rep |
| Abstract |
Atopic dermatitis (AD) presents significant therapeutic challenges due to its poorly understood etiology. Eosinophilia, a hallmark of allergic inflammation, is implicated in AD pathogenesis. Interleukin-10 (IL-10)-producing regulatory B (Breg) cells exhibit potent anti-inflammatory effects. However, their role in controlling AD-related eosinophilia is not well understood. To investigate the impact of eosinophils on AD, we employed IL-5Rα-deficient (Il5ra-/-) mice, which lack functional eosinophils. Induction of AD in these mice resulted in attenuated disease symptoms, underscoring the critical role of eosinophils in AD development. Additionally, the adoptive transfer of purified Breg cells into mice with AD significantly alleviated disease severity. Mechanistic studies revealed that IL-10 produced by Breg cells directly inhibits eosinophil activation and infiltration into the skin. In vitro experiments further confirmed that Breg cells inhibited eosinophil peroxidase secretion in an IL-10-dependent manner. Our collective findings demonstrate that IL-10 from Breg cells alleviates AD by suppressing eosinophil activation and tissue infiltration. This study elucidates a novel regulatory mechanism of Breg cells, providing a foundation for future Breg-mediated therapeutic strategies for AD. |
| Volume | 14(1) |
| Pages | 18164 |
| Published | 2024-8-6 |
| DOI | 10.1038/s41598-024-68660-9 |
| PII | 10.1038/s41598-024-68660-9 |
| PMID | 39107352 |
| PMC | PMC11303538 |
| MeSH | Adoptive Transfer Animals B-Lymphocytes, Regulatory* / immunology B-Lymphocytes, Regulatory* / metabolism Dermatitis, Atopic* / immunology Dermatitis, Atopic* / metabolism Dermatitis, Atopic* / pathology Dermatitis, Atopic* / therapy Disease Models, Animal Eosinophils* / immunology Eosinophils* / metabolism Interleukin-10* / metabolism Mice Mice, Inbred C57BL Mice, Knockout Skin / immunology Skin / metabolism Skin / pathology |
| IF | 3.998 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00995 |