RRC ID 81473
Author Park JS, Na HJ, Kim YJ.
Title The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut.
Journal Aging (Albany NY)
Abstract Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its associated diseases, influenced by the niche cells' environment. Age- and cancer-related reduction of vitamin D and its receptor levels are well documented in human clinical studies. However, the mechanisms through which the vitamin D/vitamin D receptor pathway contributes to anti-aging and extends life expectancy are not well understood. In this study, we aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging. By utilizing a well- established Drosophila midgut model for stem cell aging biology, we revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation. Additionally, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were reduced by vitamin D treatment. Our findings suggest a direct evidence of the anti-aging role of the vitamin D/vitamin D receptor pathway and provides insights into the molecular mechanisms underlying healthy aging in Drosophila.
Volume 16(3)
Pages 2005-2025
Published 2024-2-7
DOI 10.18632/aging.205518
PII 205518
PMID 38329439
PMC PMC10911382
MeSH Aging / metabolism Animals Cell Differentiation / physiology Cell Proliferation Drosophila* / physiology Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Humans Intestines Receptors, Calcitriol / genetics Vitamin D / metabolism Vitamin D / pharmacology
Resource
Drosophila DGRC#109126