論文 - 詳細
| RRC ID | 81473 |
|---|---|
| 著者 | Park JS, Na HJ, Kim YJ. |
| タイトル | The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut. |
| ジャーナル | Aging (Albany NY) |
| Abstract |
Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its associated diseases, influenced by the niche cells' environment. Age- and cancer-related reduction of vitamin D and its receptor levels are well documented in human clinical studies. However, the mechanisms through which the vitamin D/vitamin D receptor pathway contributes to anti-aging and extends life expectancy are not well understood. In this study, we aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging. By utilizing a well- established Drosophila midgut model for stem cell aging biology, we revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation. Additionally, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were reduced by vitamin D treatment. Our findings suggest a direct evidence of the anti-aging role of the vitamin D/vitamin D receptor pathway and provides insights into the molecular mechanisms underlying healthy aging in Drosophila. |
| 巻・号 | 16(3) |
| ページ | 2005-2025 |
| 公開日 | 2024-2-7 |
| DOI | 10.18632/aging.205518 |
| PII | 205518 |
| PMID | 38329439 |
| PMC | PMC10911382 |
| MeSH | Aging / metabolism Animals Cell Differentiation / physiology Cell Proliferation Drosophila* / physiology Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Humans Intestines Receptors, Calcitriol / genetics Vitamin D / metabolism Vitamin D / pharmacology |
| IF | 4.831 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 56 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.5 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109126 |