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Drosophila 7402R-1 , 7402R-2 , 7408R-2 , 7408R-3 , 10104R-2 , 10104R-3 , 6395R-1 , 6395R-2 , 3132R-1 , 3132R-3 , ... Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
C.elegans tm1978 S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.
C.elegans tm2543 , tm2134 , tm1842 , tm2181 , tm2644 , tm1937 , tm3655 Meiotic dysfunction accelerates somatic aging in Caenorhabditis elegans.
C.elegans Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans.
Mice RBRC06344 , RBRC03390 , RBRC03418 Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Yeast BY5701, Strain alias: SH5701, W303-1A S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.
Drosophila DGRC#104863 A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.
Drosophila DGRC#111923 Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
C.elegans tm1291 , tm2505 Extracellular proteostasis prevents aggregation during pathogenic attack.
Human and Animal Cells 10T1/2(RCB0247) Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.
Drosophila DGRC#112001 , DGRC#109126 Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine.
Mice RBRC06334 Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases.
Human and Animal Cells MC3T3-E1(RCB1126) 1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.
C.elegans tm1406 , tm1444 GABA receptors differentially regulate life span and health span in C. elegans through distinct downstream mechanisms.
Human and Animal Cells RAW 264(RCB0535) MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
Human and Animal Cells MG6(RCB2403) Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
C.elegans tm2182 , tm3410 , tm5782 , tm420 SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat.
DNA material mouse Period2 (-2.8 - +0.1 kb)_luciferase/pENTR-1A (RDB15083) , human Period3 (-3.1 - +0.2 kb)_luciferase/pENTR-1A (RDB15084) , human Bmal1 (-1.7 - +0.1 kb)_luciferase/pENTR-1A (RDB15085). A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans.
C.elegans tm3886 Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.
C.elegans tm1011 , tm1231 , tm2182 , tm331 , tm420 Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.