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  • Search Condition : Filter (MeSH = Aging / metabolism)
Species Resource Title
Mice RBRC06344 , RBRC03390 , RBRC03418 Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Yeast BY5701, Strain alias: SH5701, W303-1A S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.
Drosophila DGRC#104863 A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.
Drosophila DGRC#111923 Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
C.elegans tm1291 , tm2505 Extracellular proteostasis prevents aggregation during pathogenic attack.
Human and Animal Cells 10T1/2(RCB0247) Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.
Drosophila DGRC#112001 , DGRC#109126 Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine.
Mice RBRC06334 Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases.
Human and Animal Cells MC3T3-E1(RCB1126) 1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.
C.elegans tm1406 , tm1444 GABA receptors differentially regulate life span and health span in C. elegans through distinct downstream mechanisms.
Human and Animal Cells RAW 264(RCB0535) MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
Human and Animal Cells MG6(RCB2403) Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
C.elegans tm2182 , tm3410 , tm5782 , tm420 SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat.
DNA material mouse Period2 (-2.8 - +0.1 kb)_luciferase/pENTR-1A (RDB15083) , human Period3 (-3.1 - +0.2 kb)_luciferase/pENTR-1A (RDB15084) , human Bmal1 (-1.7 - +0.1 kb)_luciferase/pENTR-1A (RDB15085). A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans.
C.elegans tm3886 Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.
C.elegans tm1011 , tm1231 , tm2182 , tm331 , tm420 Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Mice RBRC02975 Cardioprotection and lifespan extension by the natural polyamine spermidine.
Drosophila DGRC#105467 A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline.
Drosophila 10814R-2 , 10814R-4 Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age.
C.elegans tm1944 Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.