論文 - 詳細
| RRC ID | 81477 |
|---|---|
| 著者 | Chatterjee P, Mukherjee S, Majumder P. |
| タイトル | Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis. |
| ジャーナル | Funct Integr Genomics |
| Abstract |
The Drosophila egg chamber (EC) starts as a spherical tissue at the beginning. With maturation, the outer follicle cells of EC collectively migrate in a direction perpendicular to the anterior-posterior axis, to shape EC from spherical to ellipsoidal. Filamentous actin (F-actin) plays a significant role in shaping individual migratory cells to the overall EC shape, like in every cell migration. The primary focus of this article is to unveil the function of different Actin Binding Proteins (ABPs) in regulating mature Drosophila egg shape. We have screened 66 ABPs, and the genetic screening data revealed that individual knockdown of Arp2/3 complex genes and the "capping protein β" (cpb) gene have severely altered the egg phenotype. Arpc1 and cpb RNAi mediated knockdown resulted in the formation of spherical eggs which are devoid of dorsal appendages. Studies also showed the role of Arpc1 and cpb on the number of laid eggs and follicle cell morphology. Furthermore, the depletion of Arpc1 and cpb resulted in a change in F-actin quantity. Together, the data indicate that Arpc1 and cpb regulate Drosophila egg shape, F-actin management, egg-laying characteristics and dorsal appendages formation. |
| 巻・号 | 24(4) |
| ページ | 120 |
| 公開日 | 2024-7-4 |
| DOI | 10.1007/s10142-024-01396-x |
| PII | 10.1007/s10142-024-01396-x |
| PMID | 38960936 |
| MeSH | Actin Capping Proteins / genetics Actin Capping Proteins / metabolism Actin-Related Protein 2-3 Complex / genetics Actin-Related Protein 2-3 Complex / metabolism Actins* / genetics Actins* / metabolism Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Female Microfilament Proteins / genetics Microfilament Proteins / metabolism Morphogenesis* / genetics Ovum / growth & development Ovum / metabolism |
| IF | 3.058 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |