RRC ID 81512
Author Yoshikawa R, Kawakami M, Yasuda J.
Title The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species.
Journal J Biol Chem
Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV), which has been reported in China, Korea, Japan, Vietnam, and Taiwan, is a causative agent of severe fever thrombocytopenia syndrome. This virus has a high mortality and induces thrombocytopenia and leukocytopenia in humans, cats, and aged ferrets, whereas immunocompetent adult mice infected with SFTSV never show symptoms. Anti-SFTSV antibodies have been detected in several animals-including goats, sheep, cattle, and pigs. However, there are no reports of severe fever thrombocytopenia syndrome in these animals. Previous studies have reported that the nonstructural protein NSs of SFTSV inhibits the type I interferon (IFN-I) response through the sequestration of human signal transducer and activator of transcription (STAT) proteins. In this study, comparative analysis of the function of NSs as IFN antagonists in human, cat, dog, ferret, mouse, and pig cells revealed a correlation between pathogenicity of SFTSV and the function of NSs in each animal. Furthermore, we found that the inhibition of IFN-I signaling and phosphorylation of STAT1 and STAT2 by NSs depended on the binding ability of NSs to STAT1 and STAT2. Our results imply that the function of NSs in antagonizing STAT2 determines the species-specific pathogenicity of SFTSV.
Volume 299(6)
Pages 104819
Published 2023-6-1
DOI 10.1016/j.jbc.2023.104819
PII S0021-9258(23)01847-1
PMID 37187292
PMC PMC10276162
MeSH Aged Animals Cattle Dogs Ferrets Humans Interferon Type I* / metabolism Mice Phlebovirus* / physiology Severe Fever with Thrombocytopenia Syndrome* / virology Sheep Signal Transduction Swine Thrombocytopenia / metabolism Viral Nonstructural Proteins* / metabolism
Resource
Human pathogenic viruses