Reference - Detail
| RRC ID | 81650 |
|---|---|
| Author | Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N. |
| Title | Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. |
| Journal | FEBS Lett |
| Abstract |
Pom121 is one of the integral membrane components of the nuclear pore complex (NPC) in vertebrate cells. Unlike rodent cells carrying a single POM121 gene, human cells possess multiple POM121 gene loci on chromosome 7q11.23, as a consequence of complex segmental-duplications in this region during human evolution. In HeLa cells, two "full-length" Pom121 are transcribed and translated by two distinct genetic loci. RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled NPCs on nuclear envelope. Pom121-depletion also induced clustering of NPCs, indicating its role on maintenance of NPC structure/organization. |
| Volume | 581(25) |
| Pages | 4910-6 |
| Published | 2007-10-16 |
| DOI | 10.1016/j.febslet.2007.09.021 |
| PII | S0014-5793(07)01003-4 |
| PMID | 17900573 |
| MeSH | 5' Flanking Region Base Sequence Cell Nucleus / ultrastructure Chromosome Mapping Cloning, Molecular Exons Gene Duplication* HeLa Cells Humans Membrane Glycoproteins / chemistry Membrane Glycoproteins / genetics* Membrane Glycoproteins / metabolism Molecular Sequence Data Nuclear Pore / ultrastructure* Protein Structure, Tertiary RNA Interference |
| IF | 3.057 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pKS-POM121A-Venus (RDB20246) pKS-POM121NC-Venus (RDB20247) |