Reference - Detail
| RRC ID | 81664 |
|---|---|
| Author | Inoue S, Masaki Y, Nakagawa S, Yokoi S. |
| Title | An evolutionarily distinct Hmgn2 variant influences shape recognition in Medaka Fish. |
| Journal | Commun Biol |
| Abstract |
Protein sequence diversification significantly impacts physiological traits. In this study, using medaka fish (Oryzias latipes), we identify a novel protein variant affecting shape preference behavior. Re-analysis of sequencing data reveals that LOC101156433 encodes a unique Hmgn2 variant with unusual subnuclear localization, clustered separately from the Hmgn2 clades of other species. Medaka mutants with this variant showed reduce telencephalic regions and altered shape preference, suggesting a link between protein sequence variation and behavioral changes. Additionally, this Hmgn2 variant is common in Acanthopterygii fishes, which are adapted to a variety of environments, indicating its potential evolutionary significance. Our findings highlight the relationship between amino acid sequence variation and the development of new molecular and behavioral adaptations, providing insights into the visual shape perception system in fish. |
| Volume | 7(1) |
| Pages | 973 |
| Published | 2024-8-23 |
| DOI | 10.1038/s42003-024-06667-8 |
| PII | 10.1038/s42003-024-06667-8 |
| PMID | 39179658 |
| PMC | PMC11344144 |
| MeSH | Amino Acid Sequence Animals Biological Evolution Evolution, Molecular Fish Proteins* / genetics Fish Proteins* / metabolism Oryzias* / genetics Phylogeny |
| IF | 4.165 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Medaka | d-rR/TOKYO (MT837) ohmgn2^delta2 (MT1711) ohmgn2^delta3kb (MT1712) |