RRC ID 81691
Author Saegusa C, Mutai H, Saeki T, Matsuzaki S, Mizukoshi A, Kitajiri SI, Matsunaga T, Hosoya M, Okano H, Fujioka M.
Title Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene.
Journal Stem Cell Res
Abstract Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
Volume 79
Pages 103489
Published 2024-9-1
DOI 10.1016/j.scr.2024.103489
PII S1873-5061(24)00187-9
PMID 39002249
MeSH Cell Differentiation Cell Line Child Female Hearing Loss, Sensorineural* / genetics Hearing Loss, Sensorineural* / pathology Humans Induced Pluripotent Stem Cells* / metabolism Karyotype Male Mutation* Trans-Activators / genetics
Resource
Human and Animal Cells 201B7(HPS0063)