| RRC ID |
81691
|
| 著者 |
Saegusa C, Mutai H, Saeki T, Matsuzaki S, Mizukoshi A, Kitajiri SI, Matsunaga T, Hosoya M, Okano H, Fujioka M.
|
| タイトル |
Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene.
|
| ジャーナル |
Stem Cell Res
|
| Abstract |
Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
|
| 巻・号 |
79
|
| ページ |
103489
|
| 公開日 |
2024-9-1
|
| DOI |
10.1016/j.scr.2024.103489
|
| PII |
S1873-5061(24)00187-9
|
| PMID |
39002249
|
| MeSH |
Cell Differentiation
Cell Line
Child
Female
Hearing Loss, Sensorineural* / genetics
Hearing Loss, Sensorineural* / pathology
Humans
Induced Pluripotent Stem Cells* / metabolism
Karyotype
Male
Mutation*
Trans-Activators / genetics
|
| IF |
4.495
|
| リソース情報 |
| ヒト・動物細胞 |
201B7(HPS0063) |
