論文 - 詳細
| RRC ID | 82189 |
|---|---|
| 著者 | Tomihari M, Iwasaki M, Ishikawa M. |
| タイトル | Propranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells. |
| ジャーナル | Biomed Res |
| Abstract |
Previous clinical data have shown that perioperative β-blocker administration can improve lung cancer prognosis, possibly by blocking autonomic nervous system responses. This study aimed to investigate the anticancer mechanisms of the β-blockers propranolol and landiolol for human lung adenocarcinoma cells treated with noradrenaline. A549 human lung adenocarcinoma cells were exposed to each of the following alone or in combination for 2 h: medium only for naïve control; noradrenaline at a dose of 10 μmol/L; propranolol at 10 nmol/L; and landiolol at 1000 nmol/L. Cell proliferation was examined using a cell counting kit-8 assay and immunofluorescent staining of Ki67. qRT-PCR array was performed for Harvey rat sarcoma viral oncogene homolog (HRAS), transforming growth factor-beta receptor II (TGFBR2), and vascular endothelial growth factor A (VEGFA). Noradrenaline (N) showed enhanced cell proliferation compared to control, with higher Ki67 expression on immunostaining, higher HRAS and VEGFA expressions, and lower TGFBR2 expression in qRT-PCR, whereas N-propranolol and N-landiolol showed no significant changes. The present data indicated that perioperative administration of β-blockers might improve the post- operative prognosis of lung cancer via blockage of the adrenergic response. |
| 巻・号 | 45(6) |
| ページ | 253-259 |
| 公開日 | 2024-1-1 |
| DOI | 10.2220/biomedres.45.253 |
| PMID | 39581614 |
| MeSH | A549 Cells Adenocarcinoma / drug therapy Adenocarcinoma / genetics Adenocarcinoma / metabolism Adenocarcinoma / pathology Adenocarcinoma of Lung* / drug therapy Adenocarcinoma of Lung* / genetics Adenocarcinoma of Lung* / metabolism Adenocarcinoma of Lung* / pathology Adrenergic beta-Antagonists / pharmacology Cell Line, Tumor Cell Proliferation* / drug effects Gene Expression Regulation, Neoplastic / drug effects Humans Lung Neoplasms* / drug therapy Lung Neoplasms* / genetics Lung Neoplasms* / metabolism Lung Neoplasms* / pathology Morpholines* / pharmacology Norepinephrine* / pharmacology Propranolol* / pharmacology Urea* / analogs & derivatives Urea* / pharmacology Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factor A / metabolism |
| IF | 1.429 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |