論文 - 詳細
| RRC ID | 82635 |
|---|---|
| 著者 | Deminami M, Hashimoto M, Takahashi H, Harada N, Minami Y, Kitakaze T, Masuda W, Takenaka S, Inui H, Yamaji R. |
| タイトル | Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in commensal microbiota composition in mice. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Sex differences exist in the commensal microbiota that impact on multiple physiological processes in the host. Here, we examined the mechanism by which the sex differences are formed. In addition to the epithelial ductal cell, the acinar cell mass in the submandibular gland was associated with androgen-androgen receptor (AR) signaling. There was a sex difference in the formation of submandibular mucin 10 (MUC10) in SDS-PAGE. Neuraminidase treatment, which hydrolyzes terminal sialic acid, influenced the mobility shift of MUC10. Androgen-AR signaling negatively regulated St3 β-galactoside α-2,3-sialyltransferase 1 (St3gal1) and St3gal4 in the submandibular gland. There was a trend and significant sex differences in α-diversity (Shannon, p=0.09) and β-diversity (unweighted UniFrac) in oral microbiota composition, respectively. Some female-preferring bacteria including Akkermansia muciniphila can assimilate mucin by degrading terminal sialic acids. Our results indicate that androgen-AR signaling suppresses ST3GAL1 and ST3GAL4, which can influence sex differences in commensal microbiota composition. |
| 公開日 | 2024-11-21 |
| DOI | 10.1093/bbb/zbae175 |
| PII | 7906610 |
| PMID | 39572079 |
| MeSH | Androgens* / pharmacology Animals Female Glycosylation / drug effects Male Mice Mice, Inbred C57BL Microbiota* / drug effects Mucins* / metabolism Neuraminidase / metabolism Receptors, Androgen / metabolism Sex Characteristics* Sialyltransferases* / antagonists & inhibitors Sialyltransferases* / metabolism Submandibular Gland* / drug effects Submandibular Gland* / metabolism Submandibular Gland* / microbiology beta-Galactoside alpha-2,3-Sialyltransferase |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LNCap.FGC(RCB2144) |
| 実験動物マウス | RBRC01828 |