論文 - 詳細
| RRC ID | 82676 |
|---|---|
| 著者 | Ohno Y, Toshino M, Mohammed AFA, Fujiwara Y, Komohara Y, Onodera R, Higashi T, Motoyama K. |
| タイトル | Mannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophages. |
| ジャーナル | Carbohydr Polym |
| Abstract |
Methylated β-cyclodextrin (MβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the PI3K-Akt-Bad pathway. In this study, we modified MβCD with mannose (Man-MβCD) and assessed its in vitro and in vivo potential for targeting colon cancer cells expressing the mannose receptor (MR) and tumor-associated macrophages (TAM). Man-MβCD showed a significantly greater level of cellular association with colon-26 cells and M2 macrophages, and much more prominent anticancer activity than that of MβCD against MR-positive colon-26 cells. These results revealed that autophagy was the main mechanism of cell death associated with Man-MβCD. Furthermore, compared with MβCD, Man-MβCD significantly reduced tumor development following intravenous delivery to tumor-bearing mice, with no apparent side effects. Thus, Man-MβCD has the potential to be a novel anticancer drug. |
| 巻・号 | 305 |
| ページ | 120551 |
| 公開日 | 2023-4-1 |
| DOI | 10.1016/j.carbpol.2023.120551 |
| PII | S0144-8617(23)00015-2 |
| PMID | 36737200 |
| MeSH | Animals Colonic Neoplasms* / drug therapy Mannose Mice Phosphatidylinositol 3-Kinases / metabolism Tumor-Associated Macrophages beta-Cyclodextrins* / pharmacology beta-Cyclodextrins* / therapeutic use |
| IF | 7.182 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Colon-26(RCB2657) |