RRC ID |
82676
|
Author |
Ohno Y, Toshino M, Mohammed AFA, Fujiwara Y, Komohara Y, Onodera R, Higashi T, Motoyama K.
|
Title |
Mannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophages.
|
Journal |
Carbohydr Polym
|
Abstract |
Methylated β-cyclodextrin (MβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the PI3K-Akt-Bad pathway. In this study, we modified MβCD with mannose (Man-MβCD) and assessed its in vitro and in vivo potential for targeting colon cancer cells expressing the mannose receptor (MR) and tumor-associated macrophages (TAM). Man-MβCD showed a significantly greater level of cellular association with colon-26 cells and M2 macrophages, and much more prominent anticancer activity than that of MβCD against MR-positive colon-26 cells. These results revealed that autophagy was the main mechanism of cell death associated with Man-MβCD. Furthermore, compared with MβCD, Man-MβCD significantly reduced tumor development following intravenous delivery to tumor-bearing mice, with no apparent side effects. Thus, Man-MβCD has the potential to be a novel anticancer drug.
|
Volume |
305
|
Pages |
120551
|
Published |
2023-4-1
|
DOI |
10.1016/j.carbpol.2023.120551
|
PII |
S0144-8617(23)00015-2
|
PMID |
36737200
|
MeSH |
Animals
Colonic Neoplasms* / drug therapy
Mannose
Mice
Phosphatidylinositol 3-Kinases / metabolism
Tumor-Associated Macrophages
beta-Cyclodextrins* / pharmacology
beta-Cyclodextrins* / therapeutic use
|
Resource |
Human and Animal Cells |
Colon-26(RCB2657) |