論文 - 詳細
| RRC ID | 82812 |
|---|---|
| 著者 | Nakajo H, Tsuboi T, Okamoto H. |
| タイトル | The behavioral paradigm to induce repeated social defeats in zebrafish. |
| ジャーナル | Neurosci Res |
| Abstract |
Social subordination, which causes severe stress in animals, can affect animal's behaviors, homeostasis, and mental health. In rodents, experiences of repeated social defeats, but not a single defeat, induce a depression-like state. However, it is unclear whether such experiences similarly affect behaviors of other model animals than rodents. Here, we established a behavioral paradigm for repeated social defeats with zebrafish, an emerging model for behavioral neuroscience and pharmacological analysis. We put fish into repeated social subordination for 6 consecutive days. Using behaviors during fighting as indicators, we observed that experiencing repeated social defeats led to a reduction in fight frequency and duration. The continuously-defeated zebrafish failed to win even against the transgenic fish with an impaired winning-associated neural pathway. These results suggest that repeated social defeats led to demotivation to fight and to win against opponents. Moreover, they showed strong activity in the ventral habenula, an evolutionary homolog of the mammalian lateral habenula. However, unlike the mice model, the continuously-defeated zebrafish showed no change in anxiety level and sociability. Our established behavioral paradigm will be a new tool to investigate neural mechanisms underlying social defeats. |
| 巻・号 | 161 |
| ページ | 24-32 |
| 公開日 | 2020-12-1 |
| DOI | 10.1016/j.neures.2019.11.004 |
| PII | S0168-0102(19)30590-5 |
| PMID | 31711781 |
| MeSH | Animals Behavior, Animal Habenula* Mice Social Behavior Social Defeat Stress, Psychological Zebrafish* |
| IF | 2.645 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:TeTxLC |