論文 - 詳細
| RRC ID | 82843 |
|---|---|
| 著者 | Horino T, Horiguchi H, Yumoto S, Kadomatsu T, Hara Y, Yagi T, Baba Y, Miyamoto Y, Baba H, Oike Y. |
| タイトル | Angiopoietin-Like Protein 2 Expression in Tumor Cells Supports Tumor-Associated Macrophage-Induced Tumor Progression in Esophageal Cancer. |
| ジャーナル | Ann Surg Oncol |
| Abstract |
BACKGROUND:Tumor-associated macrophages (TAM), a major component of the tumor microenvironment, play key roles in tumor formation and progression; however, mechanisms underlying TAM-induced tumor progression are complex and not well known. We previously reported that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) functions as a tumor promoter in some cancer contexts. METHODS:We examined ANGPTL2 expression in paraffin-embedded tumor samples from resected specimens of 221 patients with esophageal cancer. Patients were subdivided into four groups based on immunohistochemistry scores described above: ANGPTL2-low/TAM-low, ANGPTL2-low/TAM-high, ANGPTL2-high/TAM-low, and ANGPTL2-high/TAM-high groups. Gene expression datasets of esophageal cancer cell lines were obtained from the cancer cell line encyclopedia public database. RESULTS:In this study, we demonstrate that TAM infiltration is associated with poor prognosis in patients with esophageal cancer whose tumor cells show relatively higher ANGPTL2 expression levels; however, TAM infiltration did not affect prognosis in patients with ANGPTL2-low-expressing esophageal cancer, suggesting that ANGPTL2 expression in esophageal cancer cells is required for TAM-induced tumor progression. Our analysis of public datasets indicates a potential positive correlation of ANGPTL2 expression levels with that of transforming growth factor (TGF)-β, a TAM-activating factor, in esophageal cancer cell lines. CONCLUSION:We conclude that ANGPTL2 signaling in tumor cells supports TAM-induced tumor progression and contributes to poor prognosis in patients with esophageal cancer. These findings overall provide novel insight into pro-tumor ANGPTL2 functions and illustrate the essential role of cancer cell/TAM crosstalk in cancer progression. |
| 巻・号 | 31(12) |
| ページ | 7693-7704 |
| 公開日 | 2024-11-1 |
| DOI | 10.1245/s10434-024-15557-6 |
| PII | 10.1245/s10434-024-15557-6 |
| PMID | 38981990 |
| MeSH | Aged Angiopoietin-Like Protein 2* Angiopoietin-like Proteins* / genetics Angiopoietin-like Proteins* / metabolism Biomarkers, Tumor* / genetics Biomarkers, Tumor* / metabolism Cell Proliferation Disease Progression* Esophageal Neoplasms* / genetics Esophageal Neoplasms* / metabolism Esophageal Neoplasms* / pathology Esophageal Neoplasms* / surgery Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Male Middle Aged Prognosis Survival Rate Tumor Cells, Cultured Tumor Microenvironment* Tumor-Associated Macrophages* / metabolism Tumor-Associated Macrophages* / pathology |
| IF | 4.061 |
| リソース情報 | |
| ヒト・動物細胞 | TE-8(RCB2098) |