論文 - 詳細
| RRC ID | 82856 |
|---|---|
| 著者 | Matsumoto K, Akieda Y, Haraoka Y, Hirono N, Sasaki H, Ishitani T. |
| タイトル | Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. |
| ジャーナル | Nat Commun |
| Abstract |
Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown. Using zebrafish imaging, we reveal that cell competition ensures robust patterning of the spinal cord and muscle through elimination of cells with unfit sonic hedgehog activity, driven by cadherin-mediated communication between unfit and neighbouring fit cells and subsequent activation of the Smad-Foxo3-reactive oxygen species axis. We identify Foxo3 as a common marker of loser cells in various types of cell competition in zebrafish and mice. Foxo3-mediated physiological cell competition is required for eliminating various naturally generated unfit cells and for the consequent precise patterning during zebrafish embryogenesis and organogenesis. Given the implication of Foxo3 downregulation in age-related diseases, cell competition may be a defence system to prevent abnormalities throughout development and adult homeostasis. |
| 巻・号 | 15(1) |
| ページ | 10662 |
| 公開日 | 2024-12-17 |
| DOI | 10.1038/s41467-024-55108-x |
| PII | 10.1038/s41467-024-55108-x |
| PMID | 39690179 |
| PMC | PMC11652645 |
| MeSH | Animals Body Patterning / genetics Cadherins / genetics Cadherins / metabolism Cell Competition* Embryonic Development Forkhead Box Protein O3* / genetics Forkhead Box Protein O3* / metabolism Gene Expression Regulation, Developmental Hedgehog Proteins / genetics Hedgehog Proteins / metabolism Mice Organogenesis Reactive Oxygen Species / metabolism Signal Transduction Spinal Cord / cytology Spinal Cord / embryology Spinal Cord / metabolism Zebrafish* / embryology Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 56 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Krt4p:Gal4 |