Reference - Detail
| RRC ID | 82863 |
|---|---|
| Author | Marsden KC, Granato M. |
| Title | In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation. |
| Journal | Cell Rep |
| Abstract |
Exposure to repetitive startling stimuli induces habitation, a simple form of learning. Despite its simplicity, the precise cellular mechanisms by which repeated stimulation converts a robust behavioral response to behavioral indifference are unclear. Here, we use head-restrained zebrafish larvae to monitor subcellular Ca(2+) dynamics in Mauthner neurons, the startle command neurons, during startle habituation in vivo. Using the Ca(2+) reporter GCaMP6s, we find that the amplitude of Ca(2+) signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation. Combined, our results suggest a model for habituation learning in which increased inhibitory drive from feedforward inhibitory neurons combined with decreased excitatory input from auditory afferents decreases dendritic and Mauthner neuron excitability. |
| Volume | 13(9) |
| Pages | 1733-40 |
| Published | 2015-12-1 |
| DOI | 10.1016/j.celrep.2015.10.060 |
| PII | S2211-1247(15)01249-8 |
| PMID | 26655893 |
| PMC | PMC4680997 |
| MeSH | Animals Calcium / metabolism* Calcium Signaling / drug effects Dendrites / metabolism* Dizocilpine Maleate / pharmacology Larva / metabolism Neuronal Calcium-Sensor Proteins / metabolism Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors Receptors, N-Methyl-D-Aspartate / metabolism Reflex, Startle / drug effects Strychnine / pharmacology Zebrafish / growth & development Zebrafish / metabolism |
| IF | 8.109 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | hspGFF62A |